Regina, of Denver, Colorado passed away April 24, 2018. Survived by her husband, Frank; children, Frank (Jessica), Matthew (Shana), Zachary (Taia), & Nicole (Andrew) Work; grandchildren, Frank, Vincenzo, Zane, Nicholas, Matthew, Gracie, Matthew Jr., Lilliana Canino, Giada & Aubriella Work; siblings, Richard Appugliese, Eleanor DeCarlo & Geraldine DiTirro; and many nieces & nephews. Preceded in death by infant daughter, Tara. Funeral Mass will be celebrated on Tuesday, May 1, 2018, 10 AM, Our Lady of Mt. Carmel Catholic Church, 3549 Navajo Street, Denver, Colorado 80211. Committal Service will follow at Mount Olivet Cemetery. In lieu of flowers, memorials may be made in Regina's name to St. Jude Children's Research Hospital 501 St. Jude Place Memphis, Tennessee 38105 Please share your memories of Regina and condolences with her family by signing the guestbook below.